New in box 8 pieces / Viles Expiration July 2025 Total 16 uses! Each vial contains about 2 uses. The drops can open eyes from looking tired or help eyes open wider and avoid having to contour ever day using makeup. I enjoy using them for false lashes helping lift the lid. Each dose (one drop daily) of Upneeq was shown to be effective for at least 6 hours in clinical studies. The main ingredient in Upneeq, oxymetazoline hydrochloride, is the same primary ingredient in decongestant nasal spray, such as Afrin®. In nasal spray, the ingredient works by stimulating the blood vessels to contract, while in Upneeq, this ingredient works to stimulate eyelid muscle contraction.