Perricone MD Cold Plasma Plus+ Hand Therapy hand treatment. From box: This multi-tasking powerhouse strengthens, softens, and replenishes the thin, crepey skin on the hands through intense moisturization and diminishes the look of dark spot, veins, and discoloration. This silky cream absorbs quickly and visibly firms tightens and brightens while smoothing the look of fine lines and wrinkles and improving the skin's elasticity over time.