NEW in box- sealed. SkinMedica's TNS Advanced+ Serum is a skin rejuvenating formula that visibly improves the appearance of coarse wrinkles, fine lines and sagging skin. Powered by TNS®-MR and Renessensce (RSC) Advanced, this combination encourages skin cell renewal and supports collagen and elastin levels revealing a smoother, more radiant and youthful complexion.”