PROMOGRAN PRISMA™ Matrix is comprised of a sterile, freeze dried composite of 44% oxidized regenerated cellulose (ORC), 55% collagen and 1% silver-ORC. Silver-ORC contains 25% w/w ionically bound silver, a well-known antimicrobial agent. Optimum wound environment PROMOGRAN PRISMA™ Matrix maintains a physiologically moist microenvironment at the wound surface. This environment is conducive to granulation tissue formation, epithelization and optimal wound healing. What is the role of silver in PROMOGRAN PRISMA™ Matrix? The dressing contains ionically bound silver, a well-known antimicrobial agent. Promogran and Promogran Prisma are designed to provide an optimum wound healing environment and to modify the wound biochemistry, by reducing excessive protease activity to promote healing. These dressings can be considered in a wide range of wounds to 'kick start' healing. In the presence of exudate, the PROMOGRAN PRISMA™ Matrix transforms into a soft, conformable, biodegradable gel, and thus allows contact with all areas of the wound After initial application, re-treat the wound with PROMOGRAN PRISMA™ Matrix up to every 72 hours depending upon the amount of exudate. It is not necessary to remove any residual PROMOGRAN PRISMA™ Matrix Does Prisma need to be wet? Prisma needs moisture to be effective. Apply appropriate cover dressing to maintain a moisture- balanced wound environment